Renal and Hepatic Functions After a Week of Controlled Ovarian Hyperstimulation During In Vitro Fertilization Cycles

Background One the main aspects of an in vitro fertilization (IVF) cycle is to avoid any possible systemic damage to women undergoing to a controlled ovarian hyperstimulation (COH). The aim of this work is to evaluate renal and hepatic function blood tests in patients undergoing controlled ovarian hyperstimulation during IVF cycles. MaterialsAndMethods All patients received a long stimulation protocol with GnRH analogues by daily administration since the twenty-first day of the previous ovarian cycle, followed by COH with recombinant follicle-stimulating hormone (FSH). The daily dose of exogenous gonadotropins for every single patient was modified according to her follicular growth. The oocytes were retrieved during the oocyte pick up and fertilized by standard procedures of intracytoplasmic sperm injection (ICSI). The blood samples to evaluate renal and hepatic functions were taken at the 7th day of ovarian stimulation. Results We enrolled 426 women aged between 19 and 44 years, with a mean BMI of 24.68 Kg/m2. The mean value of Blood Urea Nitrogen was 14 ± 3.16 mg/dl; creatinine: 1 ± 0.45 mg/dl; uric acid: 4 ± 1.95 mg/dl; total proteins: 7 ± 3.93 mg/dl; aspartate aminotransferase: 18 ± 6.29 mU/ml; alanine aminotransferase: 19 ± 10.41 mU/ml; alkaline phosphatase: 81 ± 45.25 mU/ml; total bilirubin 1 ± 0.35 mg/dL. All the results were considered as in a normal range following the Medical Council of Canada. Conclusion Our data suggest that, unlike patients with OHSS, the COH does not determine any alteration to renal and hepatic functions.